Select Featured Papers
Borcherding N*, Jia W*, Giwa R, Field RL, Moley JR, Kopecky BJ, Chan MM, Yang BQ, Sabio JM, Walker EC, Osorio O, Bredemeyer AL, Pietka T, Alexander-Brett J, Morley SC, Artyomov MN, Abumrad NA, Schilling J, Lavine K, Crewe C, Brestoff JR. Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood. Cell Metabolism 34(10): 1499-1513.E8, 2022. *Co-first
Rosina M, Ceci V, Turchi R, Li C, Borcherding N, Sciarretta F, Sanchez-Diaz M, Tortolici F, Keaton K, Chiurchiu V, Fuoco C, Giwa R, Field RL, Aurano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faenza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng Y-H, Hidalgo A, Zhou B, Brestoff JR, Aquilano K^, Lettieri-Barbato D^. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Cell Metabolism 34(4):533-548.e12, 2022. ^Co-corresponding.
Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, Rowen MN, Saunders BT, Ma H, Mack MR, Hykes BL, Balce DR, Orvedahl A, Williams JW, Rohatgi N, Wang X, McAllaster MR, Handley SA, Kim BS, Doench JG, Zinselmeyer BH, Diamond MS, Virgin HW, Gelman AE, Teitelbaum SL. Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity. Cell Metaboslim,33(2):270-282.e8, 2021. **Selected for Cell Metabolism Best of 2021 special issue**
Moriyama S, Brestoff JR, Flamar AL, Moeller JB, Klose CSN, Rankin LC, Yudanin NA, Monticelli LA, Putzel GG, Rodewald HR, Artis D. Beta2-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses. Science. 2018; 359(6379): 1056-1061.
Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015; 519: 242-246.
Brestoff JR and Artis D. Immune cell regulation of metabolic homeostasis in health and disease. Cell. 2015; 161(1): 146-160.
Brestoff JR and Artis D. Commensal bacteria at the interface of host metabolism and the immune system. Nature Immunology. 2013; 14(7): 676-684.
Zou W^, Rohatgi N^, Brestoff JR, Moley JR, Li Y, Williams JW, Alippe Y, Pan H, Pietka TA, Mbalaviele G, Newberry EP, Davidson NO, Dey A, Shoghi KI, Head RD, Wickline SA, Randolph GJ, Abumrad NA, Teitelbaum SL. Myeloid cell-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure. Journal of Clinical Investigation.2020; 130(5): 2644-2656. ^Co-first
Mack MR, Brestoff JR, Berrien-Elliott MM, Trier AM, Yang TB, McCullen M, Collins PL, Niu H, Bodet ND, Wagner JA, Park E, Xu AZ, Wang F, Chibnall R, Council ML, Heffington C, Kreisel F, Margolis DJ, Sheinbein D, Lovato P, Vivier E, Cella M, Colonna M, Yokoyama WM, Oltz EM, Fehniger TA, Kim BS. Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis. Science Translational Medicine. 2020; 12(532): eaay1005.
Li Y, Su X, Rohatgi N, Zhang Y, Brestoff JR, Shoghi KI, Xu Y, Semenkovich CF, Harris CA, Peterson LL, Weilbaecher KN, Teitelbaum SL, Zou W. Hepatic lipids promote liver metastasis. JCI Insight 2020; 5(17): e136215.
Zou W, Rohatgi N, Brestoff JR, Zhang Y, Scheller EL, Craft CS, Brodt MD, Migotsky N, Silva MJ, Harris CA, Teitelbaum SL. Congenital lipodystrophy induces severe osteosclerosis. PLoS Genetics. 2019; 15(6): e1008244.
Li Y, Zou W, Brestoff JR, Rohatgi N, Xiaobo W, Atkinson J, Teitelbaum SL. Fat-produced adipsin regulates inflammatory arthritis. Cell Reports. 2019; 27(10): 2809-2816.
Brestoff JR^, Afaneh K, Toland A, Press B, Westervelt P, Hassan A^. Bone marrow biopsy needle type affects core biopsy length and quality and aspirate hemodilution. American Journal of Clinical Pathology.2019; 151(2): 185-193.^Co-corresponding authors.
Rohatgi N, Zou W, Collins PL, Brestoff JR, Chen TH, Abu-Amer Y, Teitelbaum SL. ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1. Blood Adv.2018; 2(19): 2467-2477.
Kesterson K, Nahmias Z, Brestoff JR, Bodet ND, Kau A, Kim BS. Generalized pruritis relieved by NSAIDS in the setting of mast cell activation syndrome. J Allergy Clin Immunol Pract.2018; 6(6): 2130-2131.
Wilen CB, Lee S, Hsieh LY, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Zhang X, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Cadwell K, Allen PM, Handley SA, Campagne MvL, Baldridge MT, Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science.2018; 360(6385): 204-208.
Brestoff JR, Tesfazghi M, Zaydman MA, Jackups Jr R, Kim BS, Scott MG, Gronowski AM, Grossman BJ. The B antigen protects against the development red meat allergy.J Allergy Clin Immunol Pract.2018; 6(5): 1790-1791.e3.
Meisel JS, Sfyroera G, Bartow-McKenney C, Gimblet C, Bugayev J, Horwinski J, Kim B, Brestoff JR, Tyldsley AS, Zheng Q, Hodkinson BP, Artis D, Grice EA. Commensal microbiota modulate gene expression in the skin. Microbiome.2018; 6(1): 20.
Oetjen LK, Mack MR, Whelan TM, Wang PL, Niu H, Feng J, Xu AZ, Tripathi SV, Guo CJ, Luo J, Brestoff JR, Schaffer A, Hsieh C, Gereau RW, Miller MJ, Hu H, Davidson S, Liu Q and Kim BS. Neuronal IL-4Rα and JAK1 signaling mediate chronic itch. Cell.2017; 171(1): 217-228.
Williams J^, Elvington AF^, Ivanov S^, Kessler S, Luehmann H, Baba O, Saunders BT, Kim K, Johnson MW, Craft CS, Choi J, Sorci-Thomas MG, Zinselmeyer BH, Brestoff JR, Liu Yongjian, Randolph GJ. Thermoneutrality but not UCP1 deficiency suppresses monocyte mobilization into blood. Circ Res.2017; 121(6): 662-676. ^Equal contributions
Brestoff JR,Zaydman MA, Scott MG and Gronowski AM. Diagnosis of red meat allergy with antigen-specific IgE tests in serum. J Allergy Clin Immunol. 2017; 140(2): 608-609.
Brestoff JR. Isolation of immune cells from white adipose tissue for flow cytometric analysis. Methods Mol Biol.2017; 1566: 49-59
Brestoff JR, Brodsky T, Sosinsky AZ, McLoughlin R, Stansky E, Fussell L, Sheppard A, DiSanto-Rose M, Kershaw EE, Reynolds TH 4th. Manganese [III] tetrakis [5,10,15,20]-benzoic acid porphyrin reduces adiposity and improves insulin sensitivity in mice with pre-existing obesity. PLoS One.2015; 10(9): e0137388.
Kim BS, Wang K, Siracusa MC, Saenz SA, Brestoff JR, Monticelli LA, Noti M, Tait Wojno ED, Fung TC, Kubo M, Artis D. Basophils promote innate lymphoid cell responses in inflamed skin. J Immunol.2014; 193(7): 3717-3725.
Saenz SA, Siracusa MC, Monticelli LA, Ziegler CGK, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multi-potent progenitor type 2 (MPPtype2) cells. J Exp Med.2013; 210(9): 1823-1837.
Brestoff Lab at Washington University in St Louis 