Oct 4, 2022: our latest paper from the lab published in Cell Metabolism

Postdoctoral fellows Drs. Nick Borcherding (CP-PSTP) and Wentong Jia were co-first authors on our recent publication reporting that dietary long-chain fatty acids inhibit mitochondria capture by macrophages, thereby diverting adipocyte-derived mitochondria into the blood for distribution to distant organs such as the heart. Immunology PhD student Rocky Giwa made a major contribution to the paperContinue reading “Oct 4, 2022: our latest paper from the lab published in Cell Metabolism”

Dr. Wentong Jia joins the lab!

Dr. Wentong Jia, Ph.D., has officially joined the Brestoff Lab as a postdoctoral research associate. We are thrilled to welcome Dr. Jia to the group and look forward to working with him. Dr. Jia received his Bachelor’s degree in 2013 from Northwest Agriculture and Forestry University before starting his PhD training at the State KeyContinue reading “Dr. Wentong Jia joins the lab!”

Nicholas Borcherding wins ACLPS Young Investigator Award

Dr. Nicholas Borcherding, MD, PhD, MSc, was awarded a Paul E. Strandjord Young Investigator Award by the Academy of Clinical Laboratory Physicians and Scientists (ACLPS) for his abstract entitled “Mapping cell-to-cell mitochondria transfer in obesity using high-dimensional spectral flow cytometry.” Congratulations Nick!

Mitochondria transfer paper published in Cell Metabolism

Congratulations to Brestoff Lab members John Moley, Nicole Malvin, and Marina Rowen who co-authored this paper! We show that adipocytes transfer their mitochondria to macrophages in mice and that this process, which is mediated by heparan sulfates, is impaired in the setting of obesity. Genetically removing heparan sulfates from macrophages results in metabolic dysfunction characterizedContinue reading “Mitochondria transfer paper published in Cell Metabolism”